Common Questions

Frequently asked questions

Explore some common questions below

  • General

  • Can I trust Genoma?

    Genoma laboratory follows the most stringent European quality standards. Our tests have been optimized and fully validated by quality process to ensure top analytical performance. All results are reviewed and validated by a genetician registered at the Medical Laboratories of Switzerland.

  • Tranquility

  • Why should I choose Tranquility? How accurate is it?

    Tranquility provides reliable answers and is more accurate than traditional methods (biochemical screening test). Based on DNA analysis with New Generation Sequencing technology, Tranquility ensures a sensitivity (true positive rate) 99,9% for trisomy 21 (vs. 79% for traditional methods First trimester diagnosis and screening for fetal aneuploidy Deborah A. Driscoll, MD1 and Susan J. Gross, MD2, for the Professional Practice and Guidelines Committee).

    Standard screening tests fail to detect trisomy 21 in more than 15% of cases. The calculation of the fetal fraction ensures the reliability of the results. The amount of unnecessary amniocentesis is significantly reduced.

  • How does the Tranquility test works?

    Small fragments of genetic material called cell-free DNA, circulate freely in every person’s bloodstream. When you are pregnant, cell-free DNA includes not only maternal DNA but also fetal DNA from the 5th week of pregnancy.

    With a simple blood draw, Tranquility analyzes the cell-free DNA that circulates in the expecting mother’s bloodstream and detects the presence of most common chromosomal disorders. These include trisomy 21, 18 and 13, sexual aneuploidies and microdeletions. Tranquility also detects the sex of the fetus.

  • Is Tranquility easy to perform compared to traditional screening test?

    A simple blood draw is needed: your blood sample can be drawn at your doctor’s office, as early as from the 10th week of gestation (12 weeks for twin pregnancies).

  • Who should have Tranquility prenatal test?

    Any pregnant woman can perform Tranquility as a standard prenatal test without concerns as early as the 10th week of pregnancy and the 12th week for twin pregnancies. This means that whether you are carrying one or 2 babies or you had an in vitro fertilization (IVF) you can perform Tranquillity.

    Factors that may affect the performance of the test are confined placental mosaicism, vanishing twin, mother’s weight and also infections, cancers and other conditions that require blood transfusions.

  • What kind of technology is used to perform Tranquility test?

    Tranquility developed its own protocol to screen cell-free DNA based on whole genome Shotgun sequencing strategy using Next-Generation Sequencing (NGS).

    Tranquility workflow has been optimally automatized to certify consistency and reproducibility of results.

    Genoma’s world-class expertise with NGS and the company’s proprietary bioinformatics platform (InKaryo) ensures high analytical performance.

  • What are Tranquility quality standards?

    Tranquility complies with the most stringent quality standards, laws and directives in the EU and Switzerland. Swiss Quality. Tranquility collection kit includes a gel pack and thermal insulation for better sample protection.

  • When can I perform Tranquility?

    You can perform Tranquility as early as 10 weeks into your pregnancy with a simple blood draw (12 weeks for twin pregnancies).

  • How long does Tranquility take?

    Tranquility is a simple blood test that takes a couple of minutes at your healthcare provider office.

  • I am expecting twins: Can I get Tranquility prenatal test?

    Yes, you can complete Tranquility in twin pregnancies since week 12th.

  • I am expecting a baby through IVF: can I get Tranquility prenatal test?

    Yes, you can complete Tranquility in pregnancies conceived through in vitro fertilization (IVF).

  • Serenity

  • What are BRCA1 and BRCA2

    BRCA1 and BRCA2 are tumor suppressor genes that help to ensure the stability of the cell’s genetic material. When either of these genes suffers a mutation, DNA damage may not be repaired properly and cells are more likely to develop additional genetic alterations resulting in cancer.

  • What are the benefits of early screening?

    Reassurance for you and your family. If no mutation is detected, you can adhere to the general population screening guidelines?

    Reduce cancer morbidity and mortality. If a mutation is detected, you can take early preventive tailored treatment and personalized therapies to dramatically reduce your risk of cancer.

    The survival rate for both breast and ovarian cancer increases dramatically when caught at an earlier and more treatable stage

  • What is the difference with current standard procedures?

    Current standard procedures only detect present changes in the tissue that signal an already initiated tumorous progression.

  • Is Serenity test easy to perform?

    Just a risk-free buccal swab is needed. By simply rubbing the swab against the inside of your cheek for one minute, your DNA is collected to perform the test. Results are issued within 2 weeks. Genetic counseling is recommended before and after testing.

  • How accurate is Serenity compared to other genetic tests?

    Serenity screens the entire coding regions of the BRCA1 and BRCA2 genes, detecting all variants and pathogenic mutations.

    Other genetic tests don’t screen the entire BRCA1 and BRCA2 genes and/or can only detect certain mutations, or screen other genes which provide information with little or no clinical utility. They are lengthy, costly and require a blood draw.

  • Should I be tested for BRCA mutations?

    Any woman at any age is eligible to be screened. Earlier detection allows most effective preventive action for the whole family.

    The leading scientists advocate for BRCA1 and BRCA2 genetic screening for every woman at about age 30 as a part of routine medical care. Early detection of actionable mutations is vital for cancer prevention.

  • What does the test results mean?

    A pathogenic and likely pathogenic variant or deleterious mutation has a serious negative impact on the function of the gene. This means a higher risk of developing breast or ovarian cancer. It does not mean that person WILL develop cancer.

    A benign variant has no impact on the function of the gene: even with this difference in its code, there is no deleterious impact. A large amount of the population carries benign variants with no development with cancer.

    There is a third possible result, a variant of unknown significance may have an impact on the function of the gene but the cancer risk has not yet been determined yet due to low clinical cases.

    These (and all) BRCA test results are discussed with a health professional who is knowledgeable about BRCA testing.

  • How long should I wait to receive Serenity results?

    Serenity results are issued within 2 weeks after reception of the sample at Geneva laboratory.

    Current BRCA screening test delivers results within 2-3 months. With Serenity the stress caused by waiting is much reduced.

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